大肠腺瘤性息肉病
结直肠癌
Wnt信号通路
种系突变
发病机制
癌症研究
家族性腺瘤性息肉病
生殖系
基因
体细胞
癌症
大肠癌小鼠模型的建立
抑癌基因
疾病
医学
突变
生物
遗传学
免疫学
内科学
癌变
作者
Amirsaeed Sabeti Aghabozorgi,Amirhossein Bahreyni,Atena Soleimani,Afsane Bahrami,Majid Ghayour-Mobarhan,Gordon A. Ferns,Seyed Mahdi Hassanian
出处
期刊:Biochimie
[Elsevier]
日期:2019-02-01
卷期号:157: 64-71
被引量:55
标识
DOI:10.1016/j.biochi.2018.11.003
摘要
Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating mutations in a tumor suppressor gene, adenomatous polyposis coli (APC), leading to constitutive activation of the Wnt signaling pathway. This review summarizes the roles of somatic and germline mutations of the APC gene in hereditary as well as sporadic forms of CRC. We also discuss the diagnostic and prognostic value of the APC gene in the pathogenesis of CRC for a better understanding of CRC disease.
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