胶束
共聚物
原子转移自由基聚合
乙二醇
高分子化学
动态光散射
凝胶渗透色谱法
化学
叔胺
甲基丙烯酸酯
聚合
单体
聚合物
材料科学
有机化学
纳米颗粒
水溶液
纳米技术
作者
Qingqing Pan,Zhihui Zong,Jingyi Shen,Hongbao Xue,Yuji Pu
标识
DOI:10.1080/10601325.2018.1526039
摘要
A series of tertiary amine containing PHMEMA-PEG-PHMEMA ABA triblock copolymers were synthesized by atom transfer radical polymerization (ATRP) using bromine-capped poly(ethylene glycol) (Br-PEG-Br) and 2-(hexamethyleneimino)ethyl methacrylate (HMEMA) as macro-initiator and monomers, respectively. The chemical structures and molecular weights of triblock copolymers were characterized by 1H NMR and gel permeation chromatography (GPC). The self-assembly behaviors of copolymers in different pH conditions were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Triblock copolymers self-assembled into micelles in water (pH 7.4) and the micelles disassembled at acidic pH (pH 5.0). Anticancer drug doxorubicin (DOX) was used as a drug model and physically encapsulated into polymeric micelles. The drug release of DOX-loaded polymeric micelles was pH-responsive; the drug-loaded micelles that had higher contents of tertiary amine in polymer pendant groups showed faster release speed. In addition, the drug-loaded micelles showed excellent inhibition efficacy against HeLa cells in vitro.
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