兴奋剂
脑出血
小胶质细胞
阿莫地喹
医学
纹状体
药理学
神经科学
炎症
麻醉
受体
免疫学
内科学
生物
多巴胺
氯喹
蛛网膜下腔出血
疟疾
作者
Keiji Kinoshita,Kosei Matsumoto,Yuki Kurauchi,Akinori Hisatsune,Takahiro Seki,Hiroshi Katsuki
标识
DOI:10.1016/j.jneuroim.2019.02.010
摘要
Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH). Here we show that a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH. Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i.p.) from 3 h after ICH induction diminished perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppressed ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. These results suggest that Nurr1 serves a novel target for ICH therapy.
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