纳米囊
体内
罗丹明
荧光
材料科学
荧光光谱法
罗丹明B
光谱学
循环系统
生物物理学
纳米技术
生物医学工程
化学工程
化学
光学
医学
生物化学
纳米颗粒
内科学
生物
物理
生物技术
光催化
量子力学
催化作用
工程类
作者
Yana V. Tarakanchikova,Olga Stelmashchuk,Evgeniya Seryogina,Gennadii Piavchenko,Evgeny Zherebtsov,Andrey V. Dunaev,А. П. Попов,Igor Meglinski
标识
DOI:10.1088/1612-202x/aad857
摘要
Modern fluorescent modalities play an important role in the functional diagnostic of various physiological processes in living tissues.Utilizing the fluorescence spectroscopy approach we observe the circulation of fluorescent-labelled nanocapsules with rhodamine tetramethylrhodamine in a microcirculatory blood system.The measurements were conducted transcutaneously on the surface of healthy Wistar rat thighs in vivo.The administration of the preparation capsule suspension with a rhodamine concentration of 5 mg kg -1 of the animal weight resulted in a two-fold increase of fluorescence intensity relative to the baseline level.The dissemination of nanocapsules in the adjacent tissues via the circulatory system was observed and assessed quantitatively.The approach can be used for the transdermal assessment of rhodamine-loaded capsules in vivo.
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