细胞器
胚胎干细胞
过程(计算)
细胞生物学
细胞迁移
生物
基础研究
细胞
纳米技术
计算生物学
计算机科学
材料科学
生物化学
基因
操作系统
图书馆学
作者
Yu Zhang,Minghui Zhang,Zhuoyi Xie,Yubo Ding,Jialu Huang,Yao Jian,Yufan Lv,Jianhong Zuo
出处
期刊:Cancers
[MDPI AG]
日期:2022-12-26
卷期号:15 (1): 134-134
被引量:1
标识
DOI:10.3390/cancers15010134
摘要
Migrasomes are organelles that are similar in structure to pomegranates, up to 3 μm in diameter, and contain small vesicles with a diameter of 50-100 nm. These membranous organelles grow at the intersections or tips of retracting fibers at the back of migrating cells. The process by which cells release migrasomes and their contents outside the cell is called migracytosis. The signal molecules are packaged in the migrasomes and released to the designated location by migrasomes to activate the surrounding cells. Finally, the migrasomes complete the entire process of information transmission. In this sense, migrasomes integrate time, space, and specific chemical information, which are essential for regulating physiological processes such as embryonic development and tumor invasion and migration. In this review, the current research progress of migrasomes, including the discovery of migrasomes and migracytosis, the structure of migrasomes, and the distribution and functions of migrasomes is discussed. The migratory marker protein TSPAN4 is highly expressed in various cancers and is associated with cancer invasion and migration. Therefore, there is still much research space for the pathogenesis of migratory bodies and cancer. This review also makes bold predictions and prospects for the research directions of the combination of migrasomes and clinical applications.
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