氰化
化学
催化作用
组合化学
级联
基质(水族馆)
铜
自由基环化
级联反应
立体化学
有机化学
色谱法
海洋学
地质学
作者
Wen Li,Liang Wang,Haiping Mu,Qian Zhang,Zeguo Fang,Dong Liu
摘要
A convenient copper-catalyzed cascade cyclization/cyanation reaction for the construction of cyano-containing γ-lactams was developed. The protocol employed TMSCN as the cyano source and proceeded in water under simple conditions. Mechanistic studies indicated this reaction involved an amidyl radical initiated cascade 5-exo-trig cyclization/cyanation process. It is capable of generating a series of cyano-substituted γ-lactams and relative 2-oxazolidinone derivatives with a broad substrate scope.
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