微泡
转移
癌症研究
肺癌
整合素
肿瘤微环境
焦点粘着
巨噬细胞
癌细胞
医学
癌症
细胞迁移
细胞粘附
细胞
生物
体外
病理
内科学
小RNA
肿瘤细胞
基因
生物化学
遗传学
作者
Lamei Huang,Fang Wang,Xueping Wang,Chaoyue Su,Shengxi Wu,Chonglin Yang,Min Luo,Jianye Zhang,Liwu Fu
出处
期刊:MedComm
[Wiley]
日期:2022-12-23
卷期号:4 (1)
被引量:12
摘要
Metastasis is the most prevalent cause of cancer deaths, and immunological components of the tumor microenvironment, especially tumor-associated macrophages (TAMs), play a vital role in cancer metastasis. However, the underlying mechanisms of TAMs on non-small-cell lung cancer (NSCLC) metastasis remain largely unexplored. Herein, we demonstrated that M2-like TAMs facilitate the migration and invasion of cancer cells in vitro and in vivo through intercellular delivery of M2-like macrophage-derived exosomes (M2-exos). Importantly, we found that M2-exos had considerably higher levels of integrin (ITG) αV and β3. The impact of M2-like macrophage-mediated invasion and migration of NSCLC cells was clearly decreased when ITG αVβ3 was blocked. Mechanistically, exosomal ITG αVβ3 produced from M2-like macrophages successfully triggered the focal adhesion kinase signaling pathway in recipient cells, boosting the migratory and invasive abilities of NSCLC cells. Clinically, we found that metastatic NSCLC patients had greater ITG αV and β3 expression, which was associated with a worse prognosis. This study reveals a novel mechanism by which M2-exos significantly increased NSCLC cell migration and invasion by delivering integrin αVβ3. Exosomal ITG αVβ3 can be used as a potential prognostic marker, and blocking ITG αVβ3 could be a viable treatment option for preventing tumor metastasis.
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