Synthesis and Anti‐Inflammatory Activity of Spiropyrimido[4,5‐d]pyrimidine Derivatives

Abstract Herein, we describe the high yielding synthesis of spiropyrimido[4,5‐ d ]pyrimidines by Friedländer‐type reaction of substituted 4‐aminopyrimidine‐5‐carbonitriles with cyclohexanone, using sodium ethoxide as catalyst. The biological activity of the new compounds as anti‐inflammatory agents was evaluated and to predict their pharmacological properties a comprehensive in silico analysis was conducted. Among the tested compound, three compounds exhibited a potent lipoxygenase inhibitory activity comparing very well with reference octyl gallate.