Two new catechins from Zijuan green tea enhance the fitness and lifespan of Caenorhabditis elegans via insulin-like signaling pathways

Two new catechins, zijuanin E (1) and zijuanin F (2), were isolated from Zijuan green tea. 1 and 2 (100 μM) prolonged the lifespan of C. elegans by 67.2% and 56.0%, respectively, delaying the age-related decline of phenotypes, enhancing stress resistances, and reducing ROS and lipid accumulation.