介孔材料
聚合
成核
材料科学
纳米技术
药物输送
纳米颗粒
聚合物
化学
有机化学
催化作用
作者
Min Guo,Runfeng Lin,Wenqing Xu,Lihui Xu,Minchao Liu,Xirui Huang,Jie Zhang,Xingjin Li,Yanming Ma,Minjia Yuan,Qi Li,Qiang Dong,Xiaomin Li,Tiancong Zhao,Dongyuan Zhao
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-10-22
卷期号:18 (44): 30605-30615
被引量:1
标识
DOI:10.1021/acsnano.4c09326
摘要
Directly assembling drugs into mesoporous nanoformulations will be greatly favored due to the combination of enhanced drug delivery efficiency and mesostructure-enabled nanobio interactions. However, such an approach is hindered due to the lack of understanding of polymer nanoparticles' formation mechanism, especially the relationship between polymerization, self-assembly, and the nucleation process. Here, by investigating the levodopa and dopamine polymerization process, we identify π-cation interaction as pivotal in the self-assembly and nucleation control of dopa molecules. Thus, through manipulation of the π-cation interaction, we present the direct assembly of a commercial drug, levodopa, into mesoporous nanoformulations. The synthesized nanospheres, approximately 200 nm in diameter, exhibit uniform mesopores of around 8 nm. These nanoformulations, abundant in mesopores, enhance chiral phenylalanine interaction with α-synuclein (Syn), curbing aggregation, safeguarding neurons, and alleviating Parkinson's pathology. When combating α-synuclein, the nanoformulation achieved ∼100% inhibition of protein aggregation and sustained neuron viability up to 300%. We believe that this study may advance mesoscale self-assembly knowledge, guiding future nanopharmaceutical developments.
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