Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose

Conventional glassy carbon electrodes (GCE) cannot meet the requirements of future electrodes for wider use due to low conductivity, high cost, non-portability, and lack of flexibility. Therefore, cost-effective and wearable electrode enabling rapid and versatile molecule detection is becoming important, especially with the ever-increasing demand for health monitoring and point-of-care diagnosis. Graphene is considered as an ideal electrode due to its excellent physicochemical properties. Here, we prepare graphene film with ultra-high conductivity and customize the 3-electrode system via a facile and highly controllable laser engraving approach. Benefiting from the ultra-high conductivity (5.65 × 105 Sm−1), the 3-electrode system can be used as multifunctional electrode for direct detection of dopamine (DA) and enzyme-based detection of glucose without further metal deposition. The dynamic ranges from 1–200 µM to 0.5–8.0 mM were observed for DA and glucose, respectively, with a limit of detection (LOD) of 0.6 µM and 0.41 mM. Overall, the excellent target detection capability caused by the ultra-high conductivity and ease modification of graphene films, together with their superb mechanical properties and ease of mass-produced, provides clear potential not only for replacing GCE for various electrochemical studies but also for the development of portable and highperformance electrochemical wearable medical devices.