银屑病
粪便细菌疗法
失调
银屑病性关节炎
肠道菌群
免疫学
关节炎
免疫系统
医学
发病机制
益生菌
生物
微生物学
细菌
抗生素
艰难梭菌
遗传学
作者
Yuhsien Lai,Xiangmei Wu,Ellen Chao,Joshua Bloomstein,Grace Wei,Samuel Hwang,Zhengang Shi
标识
DOI:10.1016/j.jid.2023.05.012
摘要
There is growing evidence that supports a role of gut dysbiosis in the pathogenesis of psoriasis (Pso). Thus, probiotic supplementation and fecal microbiota transplantation may serve as promising preventive and therapeutic strategies for patients with Pso. One of the basic mechanisms through which the gut microbiota interacts with the host is through bacteria-derived metabolites, usually intermediate or end products produced by microbial metabolism. In this study, we provide an up-to-date review of the most recent literature on microbial-derived metabolites and highlight their roles in the immune system, with a special focus on Pso and one of its most common comorbidities, psoriatic arthritis.
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