Clinical efficacy of adjunctive use of coenzyme Q10 in non‐surgical periodontal treatment: A systematic review

Abstract This systematic review evaluated the effects of coenzyme Q10 (CoQ10) in non‐surgical periodontal treatment (PROSPERO: CRD42022311286). Five databases were screened (up to May/2024). It included only randomized controlled trials (RCTs) of subgingival scaling root planing (SRP) with or without adjunct use of the antioxidant CoQ10 in adults with periodontitis. The risk of bias and the certainty of the evidence were assessed. Meta‐analyses were conducted to estimate mean differences for probing depth (PD) and clinical attachment level (CAL) between baseline and follow‐up. Ten studies were included, of which four administered CoQ10 locally (topical [ n = 1]; intra‐pocket [ n = 3] modalities), and six used oral supplementation. There was no significant effect of local use of CoQ10 on reduction of PD and gain in CAL. Daily oral supplementation (120 mg/day) with CoQ10 resulted in a greater mean reduction of PD by 0.41 mm (95% CI: 0.02–0.80) and a greater mean CAL gain by 0.52 mm (95% CI: 0.26–0.78) than seen in controls. Based on very low certainty of evidence, there was no significant effect of locally delivered Q10 gel on PD/CAL, but daily oral supplementation with CoQ10 resulted in better periodontal health after 12 weeks.