化学
另一个
醋酸酐
乙酰化
水溶液
有机化学
分子内力
甘露糖
碳酸钠
乙酸钠
药物化学
钠
催化作用
生物化学
基因
作者
Xin Qiu,Daniel Chong,Antony J. Fairbanks
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-03-13
卷期号:25 (11): 1989-1993
被引量:2
标识
DOI:10.1021/acs.orglett.3c00584
摘要
Unprotected sugars are selectively acetylated simply by stirring in aqueous solution in the presence of acetic anhydride and a weak base such as sodium carbonate. The reaction is selective for acetylation of the anomeric hydroxyl group of mannose, 2-acetamido, and 2-deoxy sugars and can be performed on a large scale. Competitive intramolecular migration of the 1-O-acetate to the 2-hydroxyl group when these two substituents are cis causes over-reaction and the formation of product mixtures.
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