谷氨酰胺分解
PI3K/AKT/mTOR通路
代谢途径
生物
生发中心
癌症研究
癌细胞
氧化磷酸化
癌症
信号转导
细胞生物学
生物化学
新陈代谢
B细胞
遗传学
抗体
作者
Katarína Kľučková,Annalisa D’Avola,John C. Riches
出处
期刊:Cancers
[Multidisciplinary Digital Publishing Institute]
日期:2022-11-11
卷期号:14 (22): 5552-5552
被引量:9
标识
DOI:10.3390/cancers14225552
摘要
There have been significant recent advances in the understanding of the role of metabolism in normal and malignant B-cell biology. Previous research has focused on the role of MYC and mammalian target of rapamycin (mTOR) and how these interact with B-cell receptor signaling and hypoxia to regulate glycolysis, glutaminolysis, oxidative phosphorylation (OXPHOS) and related metabolic pathways in germinal centers. Many of the commonest forms of lymphoma arise from germinal center B-cells, reflecting the physiological attenuation of normal DNA damage checkpoints to facilitate somatic hypermutation of the immunoglobulin genes. As a result, these lymphomas can inherit the metabolic state of their cell-of-origin. There is increasing interest in the potential of targeting metabolic pathways for anti-cancer therapy. Some metabolic inhibitors such as methotrexate have been used to treat lymphoma for decades, with several new agents being recently licensed such as inhibitors of phosphoinositide-3-kinase. Several other inhibitors are in development including those blocking mTOR, glutaminase, OXPHOS and monocarboxylate transporters. In addition, recent work has highlighted the importance of the interaction between diet and cancer, with particular focus on dietary modifications that restrict carbohydrates and specific amino acids. This article will review the current state of this field and discuss future developments.
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