线粒体融合
线粒体
疾病
糖尿病
生物
2型糖尿病
生物信息学
线粒体分裂
粒线体疾病
细胞生物学
医学
内科学
内分泌学
线粒体DNA
遗传学
基因
作者
Luis Miguel García-Peña,E. Dale Abel,Renata O. Pereira
出处
期刊:Diabetes
[American Diabetes Association]
日期:2024-01-19
卷期号:73 (2): 151-161
摘要
Mitochondria undergo repeated cycles of fusion and fission that regulate their size and shape by a process known as mitochondrial dynamics. Numerous studies have revealed the importance of this process in maintaining mitochondrial health and cellular homeostasis, particularly in highly metabolically active tissues such as skeletal muscle and the heart. Here, we review the literature on the relationship between mitochondrial dynamics and the pathophysiology of type 2 diabetes and cardiovascular disease (CVD). Importantly, we emphasize divergent outcomes resulting from downregulating distinct mitochondrial dynamics proteins in various tissues. This review underscores compensatory mechanisms and adaptive pathways that offset potentially detrimental effects, resulting instead in improved metabolic health. Finally, we offer a perspective on potential therapeutic implications of modulating mitochondrial dynamics proteins for treatment of diabetes and CVD. Article Highlights
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