丙酮酸激酶缺乏
丙酮酸激酶
镰状细胞特性
糖酵解
细胞
疾病
酶
医学
丙酮酸脱氢酶复合物
生物化学
生物
药理学
内科学
作者
Dina S. Parekh,William A. Eaton,Swee Lay Thein
出处
期刊:Blood
[American Society of Hematology]
日期:2023-12-20
标识
DOI:10.1182/blood.2023021167
摘要
Pyruvate kinase (PK) is a key enzyme in glycolysis, the sole source of ATP, which is essential for all energy-dependent activities of red blood cells. Activating PK shows great potential for treating a broad range of hemolytic anemias beyond PK deficiency, as they also enhance activity of wild-type PK. Motivated by observations of sickle cell complications in sickle trait individuals with concomitant PK deficiency, activating endogenous PK offers a novel and promising approach for treating patients with sickle cell disease.
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