代谢组学
计算生物学
组学
背景(考古学)
疾病
蛋白质组学
生物标志物发现
蛋白质组
鉴定(生物学)
生物信息学
转录组
生物
骨关节炎
医学
数据科学
计算机科学
病理
基因
遗传学
基因表达
古生物学
植物
替代医学
作者
Muhammad Farooq,Kelsey H. Collins,Annemarie Lang,Tristan Maerz,Jeroen Geurts,C. Ruiz-Romero,Ronald K. June,Yolande F M Ramos,Sarah J. Rice,Shabana Amanda Ali,Chiara Pastrello,Igor Jurišica,C. Thomas Appleton,Jason S. Rockel,Mohit Kapoor
标识
DOI:10.1016/j.joca.2023.11.019
摘要
Osteoarthritis (OA) is a complex disease involving contributions from both local joint tissues and systemic sources. Patient characteristics, encompassing sociodemographic and clinical variables, are intricately linked with OA rendering its understanding challenging. Technological advancements have allowed for a comprehensive analysis of transcripts, proteomes and metabolomes in OA tissues/fluids through omic analyses. The objective of this review is to highlight the advancements achieved by omic studies in enhancing our understanding of OA pathogenesis over the last three decades.We conducted an extensive literature search focusing on transcriptomics, proteomics and metabolomics within the context of OA. Specifically, we explore how these technologies have identified individual transcripts, proteins, and metabolites, as well as distinctive endotype signatures from various body tissues or fluids of OA patients, including insights at the single-cell level, to advance our understanding of this highly complex disease.Omic studies reveal the description of numerous individual molecules and molecular patterns within OA-associated tissues and fluids. This includes the identification of specific cell (sub)types and associated pathways that contribute to disease mechanisms. However, there remains a necessity to further advance these technologies to delineate the spatial organization of cellular subtypes and molecular patterns within OA-afflicted tissues.Leveraging a multi-omics approach that integrates datasets from diverse molecular detection technologies, combined with patients' clinical and sociodemographic features, and molecular and regulatory networks, holds promise for identifying unique patient endophenotypes. This holistic approach can illuminate the heterogeneity among OA patients and, in turn, facilitate the development of tailored therapeutic interventions.
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