Lung transcriptome of e-cigarette users reveals changes related to chronic lung disease

Approximately 1-in-10 adolescents use e-cigarette devices, with 25% reporting daily use [1]. Most youth who vape have never used traditional cigarettes, creating an emerging epidemic of nicotine addiction fueled by use of e-cigarettes [2]. Public perception is that e-cigarettes are less harmful than traditional cigarettes, a belief that may be fueled, in part, by a handful of tobacco industry-funded studies reporting null results in cells or animals, replicating past misinformation campaigns about traditional cigarettes [3]. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Pierre-Régis Burgel reports support for the present manuscript from Association Vaincre la Mucoviscidose, Société Française de la Mucoviscidose, Filière Maladie Rare Muco CFTR. In addition, Pierre-Régis Burgel reports grants from Vertex Pharmaceuticals, GSK; consulting fees from Astra Zeneca, Chiesi, GSK, Insmed, Vertex, Viatris, Zambon; travel support Astra Zeneca, Chiesi; outside the submitted work. Conflict of interest: No conflicts to report. Research funded by a grant from the Canadian Institute for Health Research (CIHR HEV-172883).