干细胞
再生医学
干细胞疗法
组织工程
再生(生物学)
成体干细胞
细胞疗法
细胞分化
生物
细胞生物学
医学
生物医学工程
生物化学
基因
作者
Han Han,Bi-Te Chen,Liu Yang,Yi Wang,Lei Xing,Hui Wang,Tian‐Jiao Zhou,Hu‐Lin Jiang
标识
DOI:10.1016/j.jconrel.2023.12.024
摘要
Stem cells have garnered significant attention in regenerative medicine owing to their abilities of multi-directional differentiation and self-renewal. Despite these encouraging results, the market for stem cell products yields limited, which is largely due to the challenges faced to the safety and viability of stem cells in vivo. Besides, the fate of cells re-infusion into the body unknown is also a major obstacle to stem cell therapy. Actually, both the functional protection and the fate tracking of stem cells are essential in tissue homeostasis, repair, and regeneration. Recent studies have utilized cell engineering techniques to modify stem cells for enhancing their treatment efficiency or imparting them with novel biological capabilities, in which advances demonstrate the immense potential of engineered cell therapy. In this review, we proposed that the “engineered stem cells” are expected to represent the next generation of stem cell therapies and reviewed recent progress in this area. We also discussed potential applications of engineered stem cells and highlighted the most common challenges that must be addressed. Overall, this review has important guiding significance for the future design of new paradigms of stem cell products to improve their therapeutic efficacy.
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