后代
怀孕
胎儿
微量营养素
胎盘
妊娠期糖尿病
子痫前期
医学
生理学
产科
肥胖
妊娠期
内分泌学
生物
病理
遗传学
作者
Bruna de Araújo Lima,Andréa Sanches,Maíra Schuchter Ferreira,Josilene Lopes de Oliveira,Jane K. Cleal,Letícia Ignácio-Souzaa
标识
DOI:10.1016/j.bbadis.2023.166855
摘要
Maternal obesity could impact offspring's health. During "critical period" such as pregnancy insults have a significant role in developing chronic diseases later in life. Literature has shown that diet can play a major role in essential metabolic and development processes on fetal outcomes. Moreover, the placenta, an essential organ developed in pregnancy, seems to have its functions impaired based on pre-gestational and gestational nutritional status. Specifically, a high-fat diet has been shown as a potential nutritional insult that also affects the maternal-placental axis, which is involved in offspring development and outcome. Moreover, some classes of nutrients are associated with pregnancy complications such as reduced intake of micronutrients and diabetes, preeclampsia, and preterm delivery. Thus, we will summarize the current literature on maternal environment factors that impacts the placental development and consequently the fetal an offspring health, or the maternal-placental axis, and this on fetal outcomes, metabolism, and development.
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