表皮葡萄球菌
微生物学
炎症
角质形成细胞
表皮(动物学)
生物
免疫学
金黄色葡萄球菌
特应性皮炎
化学
细菌
细胞培养
遗传学
解剖
作者
Michael R. Williams,Michelle D. Bagood,Timothy J. Enroth,Zoie L. Bunch,Nina Jiang,Edward Liu,Samia Almoughrabie,Shadi Khalil,Fengwu Li,Samantha L. Brinton,Nadja B. Cech,Alexander R. Horswill,Richard L. Gallo
出处
期刊:Cell Reports
[Cell Press]
日期:2023-08-22
卷期号:42 (9): 113024-113024
被引量:19
标识
DOI:10.1016/j.celrep.2023.113024
摘要
Staphylococcus epidermidis is a common microbe on human skin and has beneficial functions in the skin microbiome. However, under conditions of allergic inflammation, the abundance of S. epidermidis increases, establishing potential danger to the epidermis. To understand how this commensal may injure the host, we investigate phenol-soluble modulin (PSM) peptides produced by S. epidermidis that are similar to peptides produced by Staphylococcus aureus. Synthetic S. epidermidis PSMs induce expression of host defense genes and are cytotoxic to human keratinocytes. Deletion mutants of S. epidermidis lacking these gene products support these observations and further show that PSMs require the action of the EcpA bacterial protease to induce inflammation when applied on mouse skin with an intact stratum corneum. The expression of PSMδ from S. epidermidis is also found to correlate with disease severity in patients with atopic dermatitis. These observations show how S. epidermidis PSMs can promote skin inflammation.
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