Propofol infusion syndrome (PRIS) incidence and related symptoms in children: a retrospective analysis of a nationwide hospital-based database in Japan

Editor—Propofol infusion syndrome (PRIS) is a potentially fatal complication of propofol administration. PRIS is associated with mitochondrial damage and defective free fatty acid metabolism, ultimately leading to hepatomegaly, hepatic steatosis, hyperlipidaemia, metabolic acidosis, rhabdomyolysis, and myoglobinaemia. 1 Bray R.J. Propofol infusion syndrome in children. Paediatr Anaesth. 1998; 8: 491-499 Crossref PubMed Scopus (381) Google Scholar ,2 Hemphill S. McMenamin L. Bellamy M.C. Hopkins P.M. Propofol infusion syndrome: a structured literature review and analysis of published case reports. Br J Anaesth. 2019; 122: 448-459 Abstract Full Text Full Text PDF PubMed Scopus (173) Google Scholar Plasma exchange, haemodialysis, and extracorporeal circulation can provide supportive care for PRIS, but mortality remains high.