A Therapeutic System Regulating Iron Metabolism in CD63+ Macrophage Subsets Activates Anti-tumor Immunity for Bone Metastasis Therapy

macrophages. Furthermore, by inhibiting the iron storage capacity of these macrophages, siFTH1@HEV-aCD63 notably reverses their immunosuppressive effects and robustly stimulates antitumor immune responses at the metastatic sites. Overall, this study introduces a therapeutic strategy targeting abnormal iron-metabolizing macrophages, providing a promising approach for the precise regulation of metabolically dysfunctional cells in antitumor immunotherapy.