Causal relationship between selectins and endometriosis: a Mendelian randomization study

Abstract Objective : Previous observational research has indicated an association between plasma selectin family members and endometriosis, and our objective was to investigate the causal association between selectins and endometriosis. Methods : Using pooled statistics from genome-wide association studies of predominantly European ancestry and utilizing Mendelian randomization (MR), we analyzed the causal effect of the selectins E/P/L on endometriosis and the causal association of selectins with endometriosis at different sites. Results : This study revealed a causal relationship between E-selectin and endometriosis (ratio of 0.92, 95% CI (0.86, 0.98) p = 0.01). And the causal relationship between selectins and endometriosis at different sites. Conclusion : Our genetic predictions suggest that higher levels of selectins may provide protection against endogamy and may serve as therapeutic targets in the future.