Cascade reaction of o-enoyl arylisocyanide and o-hydroxy aromatic aldimine: diastereoselective access to a polycyclic spirobenzoxazine chromeno[4,3-b]pyrrole derivative

A series of structurally unusual spirobenzoxazine chromeno[4,3-b]pyrrole derivatives have been efficiently constructed in a single operation from readily available starting materials. This domino transformation forms successively three new rings and provides a fast and economic strategy with excellent diastereoselectivity.