Uncovering the genetic link between acute myocardial infarction and ulcerative colitis co-morbidity through a systems biology approach

Cardiovascular diseases especially acute myocardial infarction are the leading cause of disability and death. Atherosclerosis is the pathological basis of AMI, and chronic inflammation can accelerate the process. Ulcerative colitis is a chronic inflammatory disease associated with immunity with possible risks contributing to AMI development. However, controversy continues to surround the relationship between these two diseases. The present study unravels the pathogenesis of AMI and UC, which may provide a new perspective on the clinical management of patients with these comorbidities.