萧条(经济学)
安慰剂
医学
优势比
抗抑郁药
荟萃分析
预防复发
内科学
重性抑郁障碍
重性抑郁发作
精神科
人口
替代医学
氢化可的松
扁桃形结构
经济
病理
海马体
宏观经济学
环境卫生
作者
Paul Glue,Mary Rocco Donovan,Sheela Kolluri,Birol Emir
标识
DOI:10.3109/00048671003705441
摘要
Objective: Continuation therapy with antidepressants is recommended for depressed patients who have responded to initial treatment. We quantified its efficacy in preventing relapse of depression in a meta-analysis of 54 double-blind placebo-controlled relapse prevention studies (patient n = 9268). Method: Relapse prevention studies in primary depression and depression subtypes were identified in a systematic literature search. The primary efficacy comparison was relapse rates between active and placebo arms calculated as odds ratios (ORs) using Review Manager version 5.0. Effects of patient age, drug class, diagnostic system and duration of therapy on ORs was examined, along with ORs calculated using different statistical methods. Results: Continuation antidepressants produced robust reduction in relapse (OR = 0.35; 95%CI 0.32–0.39). Pooled ORs were not affected by patient age, drug class, depression subtype or treatment duration, and were similar when calculated by different statistical methods. Patients with primary depression diagnosed by earlier diagnostic systems had slightly lower ORs than those diagnosed using DSM criteria. Conclusions: This meta-analysis emphasizes the importance of continuation treatment following acute response in depressive disorders. The robust findings of relapse prevention designs contrast with acute antidepressant efficacy studies, and may be due to enrichment of the patient population.
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