化学
废止
串联
铑
催化作用
烷基化
药物化学
相容性(地球化学)
功能群
碳酸盐
组合化学
有机化学
复合材料
材料科学
聚合物
作者
Hongmei Xie,Yao‐Fu Zeng,Bing Shu,Jin-Yi Liang,Zhuojun Huang,Shaoyong Chen,Yi-Chuan Zheng,Yanzhi Liu,Shang‐Shi Zhang
标识
DOI:10.1021/acs.joc.1c02179
摘要
A tandem rhodium(III)-catalyzed system was established to access 3,4-dihydroisoquinolin-1(2H)-one by coupling of N-methoxy-3-methylbenzamide with 2-methylidenetrimethylene carbonate. This one-pot synthesis protocol processed smoothly under mild reaction conditions. Moreover, a total of 28 examples, broad substrate scope, and high functional-group compatibility were observed. Preliminary mechanism studies were also conducted and demonstrated that the rhodium(III) catalyst played a vital role in the C-H-allylation and N-alkylation cyclization process.
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