伤口愈合
止血
生物相容性
海绵
材料科学
肉芽组织
体内
抗菌活性
生物医学工程
传统医学
医学
外科
生物
细菌
生物技术
植物
遗传学
冶金
作者
Wen Cheng,Fangmei Zhou,Bingqi Zhu,Xinghong Ding,Jingjing Lu,Chao-Dong Qian,Xiaoqing Ye,Zhongxiang Ding
标识
DOI:10.1016/j.matdes.2021.109806
摘要
Development of a fully functional dressing that can be applied throughout wound healing remains challenging. In this study, Bletilla striata polysaccharide (BSP) and the ethanol extract of B. striata (EEB) were physically blended and vacuum freeze-dried into a new medical dressing with various functions, such as hemostasis, anti-inflammatory, antibacterial and wound healing promotion. The in vivo and in vitro blood coagulation evaluation results showed that the most obvious hemostasis effects coming from the EEB25 sponge was probably due to good water absorption capacity. The drug sensitivity test results showed that the sponges presented a good antibacterial effect originated from the addition of EEB. In addition, the EEB25 sponge showed significant anti-inflammatory effects, as well as excellent biodegradability and biocompatibility. The full-thickness wound experiment illustrated the wound healing rates of EEB25 group on the 8th day and 16th day was 82.76 ± 2.78% and 95.36 ± 3.72%, respectively, which showed significant differences (p < 0.05) in comparison to the model group. Histological observations showed that the EEB25 group formed dense collagen fibers, granulation tissue and numerous new blood vessels on the 16th day, with the skin basically cured. Therefore, BSP/EEB multifunctional composite sponge provided a new perspective for the safe application of wound dressings.
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