Terahertz scanning of the rabbit cornea with experimental UVB-induced damage: in vivo assessment of hydration and its verification

角膜 体内 眼科 辐照 角膜上皮 材料科学 生物医学工程 水肿 光学 医学 外科 生物 物理 生物技术 核物理学
作者
Е. Н. Иомдина,S. Seliverstov,Kseniya O. Teplyakova,E. V. Jani,Viktorya V. Pozdniakova,O. N. Polyakova,Gregory Goltsman
出处
期刊:Journal of Biomedical Optics [SPIE]
卷期号:26 (04) 被引量:7
标识
DOI:10.1117/1.jbo.26.4.043010
摘要

Significance: Water content plays a vital role in the normally functioning visual system; even a minor disruption in the water balance may be harmful. Today, no direct method exists for corneal hydration assessment, while it could be instrumental in early diagnosis and control of a variety of eye diseases. The use of terahertz (THz) radiation, which is highly sensitive to water content, appears to be very promising. Aim: To find out how THz scanning parameters of corneal tissue measured by an experimental setup, specially developed for in vivo contactless estimations of corneal reflectivity coefficient (RC), are related to pathological changes in the cornea caused by B-band ultraviolet (UVB) exposure. Approach: The setup was tested on rabbit eyes in vivo. Prior to the course of UVB irradiation and 1, 5, and 30 days after it, a series of examinations of the corneal state was made. At the same time points, corneal hydration was assessed by measuring RC. Results: The obtained data confirmed the negative impact of UVB irradiation course on the intensity of tear production and on the corneal thickness and optical parameters. A significant (1.8 times) increase in RC on the 5th day after the irradiation course, followed by a slight decrease on the 30th day after it was revealed. The RC increase measured 5 days after the UVB irradiation course generally corresponded to the increase (by a factor of 1.3) of tear production. RC increase occurred with the corneal edema, which was manifested by corneal thickening (by 18.2% in the middle area and 17.6% in corneal periphery) and an increased volume of corneal tissue (by 17.6%). Conclusions: Our results demonstrate that the proposed approach can be used for in vivo contactless estimation of the reflectivity of rabbit cornea in the THz range and, thereby, of cornea hydration.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wshuai发布了新的文献求助10
1秒前
shijiaoshou完成签到,获得积分10
1秒前
QQ发布了新的文献求助10
1秒前
1秒前
细腻的葵阴完成签到,获得积分10
2秒前
王勾勾完成签到,获得积分10
2秒前
韶华发布了新的文献求助10
3秒前
3秒前
4秒前
金箍棒完成签到,获得积分10
4秒前
自信的访云完成签到,获得积分10
4秒前
dropofwater完成签到,获得积分10
4秒前
嗯嗯完成签到 ,获得积分10
4秒前
雷雷完成签到,获得积分10
5秒前
果果完成签到 ,获得积分10
5秒前
杨天天完成签到,获得积分10
5秒前
5秒前
fei完成签到,获得积分10
5秒前
充电宝应助姿姿采纳,获得10
6秒前
沉吟碧云间丶完成签到,获得积分10
6秒前
wangc发布了新的文献求助30
6秒前
科研通AI5应助仪锦文采纳,获得10
6秒前
7秒前
zhi完成签到,获得积分10
7秒前
8秒前
8秒前
柠檬杨完成签到,获得积分10
9秒前
9秒前
彭于晏应助姜梦采纳,获得10
9秒前
高会和发布了新的文献求助10
9秒前
10秒前
10秒前
tjl完成签到,获得积分10
10秒前
小二郎应助tanwenbin采纳,获得10
10秒前
小二郎应助tanwenbin采纳,获得10
10秒前
隐形曼青应助tanwenbin采纳,获得10
11秒前
11秒前
11秒前
是韩东发布了新的文献求助20
12秒前
Akim应助西瓜籽采纳,获得10
12秒前
高分求助中
Technologies supporting mass customization of apparel: A pilot project 600
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
材料概论 周达飞 ppt 500
Introduction to Strong Mixing Conditions Volumes 1-3 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3808401
求助须知:如何正确求助?哪些是违规求助? 3353139
关于积分的说明 10363475
捐赠科研通 3069342
什么是DOI,文献DOI怎么找? 1685478
邀请新用户注册赠送积分活动 810551
科研通“疑难数据库(出版商)”最低求助积分说明 766193