医学
闭塞性细支气管炎
囊性纤维化
人口统计学的
疾病
儿科
肺功能
重症监护医学
肺
内科学
肺移植
人口学
社会学
作者
Y.-N. Li,L. Liu,Hanlin Cheng,Hanlin Cheng
标识
DOI:10.1016/s1526-0542(13)70062-9
摘要
The demographics of cystic fibrosis continue to change with adults outnumbering children in most developed countries. Median predicted survival is now over 40 years and 7.6% are aged >40 years. Patients surviving beyond 40 cover the full spectrum of disease from homozygous F508del to single organ disease. Differences in the characteristics of older patients are recognised, but generally patients diagnosed in adulthood are still at risk of accelerated lung function decline. Improved survival brings new challenges, including a rising rate of CF co-morbidities such as diabetes, in addition to other medical problems such as renal impairment and ototoxicity.
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