神经科学
帕尔瓦布明
自闭症
感觉系统
加巴能
精神分裂症(面向对象编程)
心理学
自闭症谱系障碍
感觉加工
基因剔除小鼠
皮质(解剖学)
生物
抑制性突触后电位
受体
发展心理学
精神科
生物化学
作者
Nadine Gogolla,Anne E. Takesian,Guoping Feng,Michela Fagiolini,Takao K. Hensch
出处
期刊:Neuron
[Elsevier]
日期:2014-08-01
卷期号:83 (4): 894-905
被引量:274
标识
DOI:10.1016/j.neuron.2014.06.033
摘要
Insular cortex (IC) contributes to a variety of complex brain functions, such as communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive content. How the IC acquires its integrative properties remains unexplored. We compared the emergence of multisensory integration (MSI) in the IC of behaviorally distinct mouse strains. While adult C57BL/6 mice exhibited robust MSI, this capacity was impaired in the inbred BTBR T+tf/J mouse model of idiopathic autism. The deficit reflected weakened γ-aminobutyric acid (GABA) circuits and compromised postnatal pruning of cross-modal input. Transient pharmacological enhancement by diazepam in BTBR mice during an early sensitive period rescued inhibition and integration in the adult IC. Moreover, impaired MSI was common across three other monogenic models (GAD65, Shank3, and Mecp2 knockout mice) displaying behavioral phenotypes and parvalbumin-circuit abnormalities. Our findings offer developmental insight into a key neural circuit relevant to neuropsychiatric conditions like schizophrenia and autism.
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