螺旋束
螺旋(腹足类)
α螺旋
反平行(数学)
螺旋
螺旋转动螺旋
结晶学
捆绑
DNA
蛋白质结构
生物物理学
化学
转录因子
生物
DNA结合蛋白
圆二色性
生物化学
物理
材料科学
基因
复合材料
磁场
量子力学
生态学
蜗牛
作者
Celia J. Harrison,Alex Böhm,Hillary C. M. Nelson
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-01-14
卷期号:263 (5144): 224-227
被引量:250
标识
DOI:10.1126/science.8284672
摘要
The structure of the DNA binding domain, determined at 1.8 angstrom resolution, contains a three-helix bundle that is capped by a four-stranded antiparallel beta sheet. This structure is a variant of the helix-turn-helix motif, typified by catabolite activator protein. In the heat shock transcription factor, the first helix of the motif (alpha 2) has an alpha-helical bulge and a proline-induced kink. The angle between the two helices of the motif (alpha 2 and alpha 3) is about 20 degrees smaller than the average for canonical helix-turn-helix proteins. Nevertheless, the relative positions of the first and third helices of the bundle (alpha 1 and alpha 3) are conserved. It is proposed here that the first helix of the three-helix bundle be considered a component of the helix-turn-helix motif.
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