Self-Driven Reactive Oxygen Species Generation via Interfacial Oxygen Vacancies on Carbon-Coated TiO2–x with Versatile Applications

The effective activation and utilization of O₂ have always been the focus of scientists because of its wide applications in catalysis, organic synthesis, life and medical science. Here, a novel method for activating O₂ spontaneously via interfacial oxygen vacancies on carbon-coated TiO_2-x to generate reactive oxygen species (ROS) with versatile applications is reported. The interfacial oxygen vacancies can be stabilized by the carbon layer and hold its intrinsic properties for spontaneous oxygen activation without light irradiation, while common surface oxygen vacancies on TiO_2-x are always consumed by the capture of H₂O to form the surface hydroxyls. Thus, O₂ absorbed at the interface of carbon and TiO_2-x can be directly activated into singlet oxygen (¹O₂) or superoxide radicals (·O₂^-), confirmed both experimentally and theoretically. These reactive oxygen species exhibit excellent performance in oxidation reactions and inhibition of MCF-7 cancer cells, providing new insight into the effective utilization of O₂ via oxygen vacancies on metal oxides.