百草枯
氧化应激
医学
胰腺损伤
内科学
内分泌学
坏死
肿瘤坏死因子α
皮下注射
细胞因子
抗氧化剂
炎症
胰腺
淀粉酶
药理学
化学
生物化学
酶
作者
Yanxia Gao,Linlin Hou,Yibo Wang,Shigong Guo,Ding Yuan,Yanan Jiang,Guoyu Duan,Yan Zhang,Zhigao Xu,Lu Che,Chien-Wen Sun,Sujuan Li,Shoutao Zhang,Tongwen Sun,Yang Li
标识
DOI:10.1016/j.etap.2020.103456
摘要
This study explores the efficacy and mechanism by which octreotide (OCT) alleviates paraquat (PQ)-induced pancreatic injury. Twenty-four adult male rats were randomly divided into three groups: the normal control (NC), PQ poisoning, and OCT treatment groups. The PQ-induced pancreatic injury rat model was established by administering PQ (120 mg/kg). Treatment group rats received OCT (8 μg/kg body weight) every 8 h by subcutaneous injection, 1 h after PQ administration. Rats were euthanized 24 h after PQ injection. Serum amylase, lipase, tumor necrosis factor-α, and interleukin-6 levels were markedly increased in the PQ group versus the NC group. In pancreatic tissue, PQ poisoning drastically induced necrosis and increased inflammatory cytokine and oxidative stress marker levels. Compared with the PQ group, OCT reduced pancreatic damage and histological scores, serum amylase, lipase, and inflammatory cytokine levels, as well as oxidative stress. OCT demonstrates protective effects against PQ-induced pancreatic damage through anti-inflammatory and antioxidant actions.
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