Forced Degradation as an Integral Part of HPLC Stability-Indicating Method Development

Forced degradation or accelerated degradation may be a method whereby the natural degradation rate of a product or material is redoubled by the appliance of an extra stress.  Forced degradation studies are generally opted to identify reactions which occur to degrade the processed product typically conducted before final formulation; forced degradation uses external stresses to speedily screen material stabilities. Longer term storage tests are typically wont to measure similar properties once final formulations square measure concerned thanks to the demanding office laws. These tests square measure usually costlier (because of the time involved) than forced degradation that is thus used for fast choice and elimination tests