生物标志物
医学
头颈部
肿瘤科
头颈部癌
阶段(地层学)
生物标志物发现
病理
内科学
癌症
外科
蛋白质组学
生物
生物化学
基因
古生物学
作者
Heleen Konings,Sofie Stappers,Margot Geens,Benedicte Y. De Winter,Kevin Lamote,Jan P. van Meerbeeck,Pol Specenier,Olivier M. Vanderveken,Kristien J. Ledeganck
标识
DOI:10.3389/fonc.2020.01020
摘要
Head and neck neoplasms have a poor prognosis because of their late diagnosis. Finding a biomarker to detect these tumors in an early phase could improve the prognosis and survival rate. This literature review provides an overview of biomarkers, covering the different -omics fields to diagnose head and neck neoplasms in the early phase. To date, not a single biomarker, nor a panel of biomarkers for the detection of head and neck tumors has been detected with clinical applicability. Limitations for the clinical implementation of the investigated biomarkers are mainly the heterogeneity of the study groups (e.g., small population in which the biomarker was tested, and/or only including high-risk populations) and a low sensitivity and/or specificity of the biomarkers under study. Further research on biomarkers to diagnose head and neck neoplasms in an early stage, is therefore needed.
科研通智能强力驱动
Strongly Powered by AbleSci AI