[Outcomes of pregnancy among women with alpha-thalassemia minor: A retrospective study of Pingguo county in Guangxi Zhuang Autonomous Region].

Objective: To investigate the association between the value of α-thalassemia minor and the outcomes in pregnant women. Methods: A total of 445 pregnant women with α-thalassemia minor were selected as thalassemia group in the Pingguo County Maternal and Child Health Hospital of Guangxi from January 2011 to December 2015, with ratio of 1∶4 healthy pregnant women was randomly recruited as non-thalassemia group. Clinical characteristics and pregnancy outcomes of the two groups were retrospectively analyzed using methods including t test, χ(2) test, and logistic regression model and ROC curve. Results: There were no significant differences noticed in factors as age, BMI, gestational age and educational level of the two groups. Hemoglobin of the thalassemia group was significantly lower than that of the non-thalassemia group (P<0.001). Differences on parity, ethnicities or occupation were statistically significant. Results from univariate analysis showed that the proportions of low birth weight, small for date infant and 1 min Apgar score<7 were higher in the thalassemia group, but the ratio of adverse pregnancy outcomes was comparable on parameters as preterm birth, stillbirth, macrosomia. Findings from the unconditional logistic regression showed that pregnancy complicated with α-thalassemia minor appeared a risk for both newborns with low birth weight (aOR=2.29, 95%CI: 1.32-3.95) and small for date infant (aOR= 2.11, 95%CI: 1.16-3.84). The ROC curve showed that α-thalassemia minor combined with multiple indicators presented a certain predictive value on neonatal birth weight. Conclusion: Pregnancy complicated with α-thalassemia minor was likely to increase the risk of birth weight loss in newborns, suggesting that prenatal care for pregnant women with thalassemia be strengthened, in order to reduce the incidence of adverse pregnancy outcomes.目的： 探讨孕妇妊娠合并轻型α-地中海贫血（α-地贫）对妊娠结局的影响。 方法： 选择2011年1月至2015年12月在广西壮族自治区平果县妇幼保健院产前系统检查并患有轻型α-地贫的孕妇共445例作为地贫组，按1∶4比例随机选择同期本院就诊的健康孕妇作为非地贫组，收集研究对象临床特征和妊娠结局资料，使用t检验、χ(2)检验、logistic回归模型和ROC曲线对资料进行回顾性分析。 结果： 两组孕妇年龄、BMI、孕周及文化程度差异无统计学意义，而地贫组血红蛋白明显低于非地贫组（P<0.001），两组孕妇的产次、民族和职业差异有统计学意义；单因素分析，地贫组低出生体重儿、足月小样儿和1 min Apgar评分<7所占比例高于非地贫组，而两组孕妇的早产、死胎、巨大儿等不良妊娠结局差异无统计学意义；非条件logistic回归分析，妊娠合并轻型α-地贫是低出生体重儿（aOR=2.29，95%CI：1.32~3.95）和足月小样儿（aOR=2.11，95%CI：1.16~3.84）的危险因素；受试者工作特征曲线结果表明，轻型α-地贫疾病联合多项指标对新生儿出生体重有一定的预测价值。 结论： 孕妇妊娠合并轻型α-地贫可能增加新生儿出生体重降低的风险，应加强地贫孕妇的产前检查，减少不良妊娠结局的发生。.