生物
增强子
猕猴
皮质激素生成
染色质
恒河猴
人类基因组
基因组
人类遗传学
后生
人脑
计算生物学
进化生物学
神经科学
铝元素
转录因子
基因
遗传学
基因表达
胚胎干细胞
DNA甲基化
作者
Xin Luo,Yuting Liu,Dachang Dang,Ting Hu,Yingping Hou,Xiaoyu Meng,Fengyun Zhang,Tingting Li,Can Wang,Min Li,Haixu Wu,Qingwu Shen,Yan Hu,Xuerui Zeng,Xiaorong He,Lei Yan,Shihua Zhang,Cheng Li,Bing Su
出处
期刊:Cell
[Elsevier]
日期:2021-02-01
卷期号:184 (3): 723-740.e21
被引量:69
标识
DOI:10.1016/j.cell.2021.01.001
摘要
Elucidating the regulatory mechanisms of human brain evolution is essential to understanding human cognition and mental disorders. We generated multi-omics profiles and constructed a high-resolution map of 3D genome architecture of rhesus macaque during corticogenesis. By comparing the 3D genomes of human, macaque, and mouse brains, we identified many human-specific chromatin structure changes, including 499 topologically associating domains (TADs) and 1,266 chromatin loops. The human-specific loops are significantly enriched in enhancer-enhancer interactions, and the regulated genes show human-specific expression changes in the subplate, a transient zone of the developing brain critical for neural circuit formation and plasticity. Notably, many human-specific sequence changes are located in the human-specific TAD boundaries and loop anchors, which may generate new transcription factor binding sites and chromatin structures in human. Collectively, the presented data highlight the value of comparative 3D genome analyses in dissecting the regulatory mechanisms of brain development and evolution.
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