动力学分辨率
电泳剂
对映选择合成
化学
催化作用
磷酸
轴对称性
组合化学
有机化学
物理
量子力学
作者
Fei Jiang,Ke-Wei Chen,Ping Wu,Yu‐Chen Zhang,Yinchun Jiao,Feng Shi
标识
DOI:10.1002/anie.201908279
摘要
A new strategy for enantioselective synthesis of axially chiral naphthyl-indoles has been established through catalytic asymmetric addition reactions of racemic naphthyl-indoles with bulky electrophiles. Under chiral phosphoric acid catalysis, azodicarboxylates and o-hydroxybenzyl alcohols served as bulky but reactive electrophiles that were attacked by C2-unsubstituted naphthyl-indoles, which underwent a dynamic kinetic resolution to afford two series of axially chiral naphthyl-indoles in good yields (up to 98 %) and high enantioselectivities (up to 98:2 er).
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