化学
信使核糖核酸
T细胞
细胞生物学
免疫
免疫系统
分子生物学
T淋巴细胞
Cd4 t细胞
基因表达
生物
细胞
细胞免疫
细胞免疫
细胞毒性T细胞
生物化学
先天免疫系统
作者
Yan Zhou,Weixiang Gao,Xiaonan Huang,Yumeng Yan,Sihua Wu,Xiangfei Shan,Shaoyi Chen,Mantang Qiu,Guanghui Ma,Yufei Xia
标识
DOI：10.1016/j.xcrm.2026.102667
摘要
T cell responses lasting up to 300 days and expands the T cell repertoire in mice compared to the AS01-adjuvanted Shingrix vaccine. Furthermore, LSE elicits potent protective and therapeutic effects against B16-OVA and LLC-NY-ESO1 inoculation in mice. These results indicate the potential of spatially controlled mRNA delivery for enhanced mRNA vaccinations.
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(2025-6-4)
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