铜
核化学
螯合作用
涂层
羧甲基纤维素
扫描电子显微镜
化学
材料科学
体内
抗菌活性
热稳定性
冶金
纳米技术
无机化学
复合材料
细菌
有机化学
钠
生物技术
生物
遗传学
作者
Zhifei Yang,Feng Feng,Wenwen Jiang,Le Ma,Mingzhuo Liu,Kai Li,Yizao Wan,Haiyong Ao
出处
期刊:Biomaterials advances
日期:2022-03-01
卷期号:134: 112591-112591
被引量:22
标识
DOI:10.1016/j.msec.2021.112591
摘要
Improving antibacterial performance is one of the prerequisites for the clinical application of bacterial cellulose (BC)-based dressings. In this study, a novel copper (Cu) ion loaded BC-based antibacterial wound dressing was prepared via codeposition of polydopamine (PDA) and copper ion. The scanning electron microscope (SEM) results showed that the copper ion/PDA coating was more uniform than the PDA coating, and the 3D nanopore structure of BC was retained in Cu2+@PBC. Cu ions were immobilized by forming a chelate with PDA. The thermal stability and mechanical properties of the Cu2+@PBC dressing decreased with the addition of copper ions. Cu2+@PBC-2 film with a certain amount of copper sulfate used (10 nM) exhibited favorable antibacterial properties against both S. aureus and E. coli without obvious cytotoxicity. The results of the in vivo study also demonstrated that the Cu2+@PBC-2 film can eliminate S. aureus infections and inflammatory response, promote collagen deposition, capillary angiogenesis, hair follicle growth and wound healing. These results suggest that the Cu2+@PBC-2 film has prospective application as a wound dressing.
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