化学
氢原子
分子内力
电化学
Atom(片上系统)
氢
基质(水族馆)
组合化学
表面改性
范围(计算机科学)
立体化学
有机化学
物理化学
群(周期表)
计算机科学
程序设计语言
嵌入式系统
地质学
海洋学
电极
作者
Jeongwoo Sim,Bokyeong Ryou,Minyeong Choi,Changju Lee,Cheol‐Min Park
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-06-08
卷期号:24 (23): 4264-4269
被引量:7
标识
DOI:10.1021/acs.orglett.2c01528
摘要
We describe the electrochemical α-amidoalkylation of γ-lactams based on transition-metal-free cross-coupling via hydrogen atom transfer. The highly selective hydrogen atom transfer process allows for a broad substrate scope including both inter- and intramolecular reactions. Also, the construction of quaternary centers was realized by a double hydrogen atom transfer protocol to afford spirocycles. Detailed mechanistic studies including experimental and computational studies are provided to support the reaction pathway.
科研通智能强力驱动
Strongly Powered by AbleSci AI