Generation of induced pluripotent stem cell line (ZZUi0021-A) from a patient with spinocerebellar ataxia type 19

• We obtained dermal fbroblasts from the patient and transduced successfully with Sendai viruses, encoding OCT4, SOX2, KLF4 and c-myc. • Spinocerebellar ataxia type 19 is an rare autosomal dominant cerebellar ataxia hereditary that caused by the KCND3 gene mutation. • The cell line (ZZUi0021-A) provides an ideal cell model for elucidating SCA19 pathogenesis. Spinocerebellar ataxia type 19 (SCA19) is an extremely rare autosomal dominant cerebellar ataxia hereditary that caused by the KCND3 gene mutation. And has a complex pathogenesis. At present, its pathogenesis is still unclear, and there is no effective treatment for SCA19. So, to study its pathogenesis and find effective treatments, we collected the fifibroblasts from a patient with SCA19, then successfully transformed the fifibroblasts into induced pluripotent stem cells (iPSCs) and construct a SCA19 pathological cell mode. This study provides a basis for elucidating its pathogenesis and providing new treatment options.