神经保护
氧化应激
睡眠剥夺
白藜芦醇
神经炎症
药理学
谷胱甘肽过氧化物酶
内分泌学
内科学
化学
医学
神经科学
炎症
生物
超氧化物歧化酶
认知
作者
Yujuan Li,Zhiyong Xie,Xiaoxiao Luo,Xuan Wang,Yue Wang,Mingke Guo,Zhiqiang Zhou,Renhua Sun,Hua Duan,Ai-lun Luo,Shiyong Li
标识
DOI:10.1002/mnfr.202200735
摘要
Sleep deprivation (SD) negatively affects all aspects of health, with one serious consequence being impaired cognition. Farnesol (FOL) is a sesquiterpene synthesized by plants and mammals that has antioxidant, anti-inflammatory, and neuroprotective properties. This study investigates the mechanism underlying the neuroprotective effect of FOL on SD-induced cognitive impairment.Administration of FOL dramatically ameliorates chronic sleep deprivation (CSD)-induced cognitive impairment. In addition, FOL notably attenuates oxidative stress damage, pro-inflammatory cytokines activation, and microglial activation in the hippocampi of the CSD-exposed mice. Further examination indicates that administration of FOL after the CSD significantly increases the protein expressions of silent information regulator factor 2-related enzyme 1 (Sirt1), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and glutathione peroxidase 4 (Gpx4) in the hippocampi. Sirt1 agonist resveratrol (RES) has a similar neuroprotective effect, indicating that FOL could exert neuroprotective effects through the activation of the Sirt1/Nrf2 signaling pathway.The results reveal that FOL could protect against CSD-induced cognitive impairment by activating the Sirt1/Nrf2 signaling pathway.
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