哌嗪
生物合成
生物碱
化学
酶
血红素
生物化学
立体化学
组合化学
有机化学
作者
Mai-Truc Pham,Yang Fu,I-Chen Liu,Po‐Huang Liang,Hsiao‐Ching Lin
标识
DOI:10.1002/anie.202401324
摘要
We report the discovery and biosynthesis of new piperazine alkaloids‒arizonamides, and their derived compounds‒arizolidines, featuring heterobicyclic and spirocyclic isoquinolone skeletons, respectively. Their biosynthetic pathway involves two crucial non‐heme iron enzymes, ParF and ParG, for core skeleton construction. ParF has a dual function facilitating 2,3‐alkene formation of helvamide, as a substrate for ParG, and oxidative cleavage of piperazine. Notably, ParG exhibits catalytic versatility in multiple oxidative reactions, involving cyclization and ring reconstruction. A key amino acid residue Phe67 was characterized to control the formation of the constrained arizonamide B backbone by ParG.
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