淋巴细胞白血病
CD19
医学
白血病
急性淋巴细胞白血病
免疫学
内科学
肿瘤科
癌症研究
抗原
作者
Regina M. Myers,Kaitlin Devine,Yimei Li,Sophie Lawrence,Allison Barz Leahy,Hongyan Liu,Lauren Vernau,Colleen Callahan,Diane Baniewicz,Stephan Kadauke,Regina McGuire,Gerald Wertheim,Irina Kulikovskaya,Vanessa Gonzalez,Joseph A. Fraietta,Amanda M. DiNofia,Stephen P. Hunger,Susan R. Rheingold,Richard Aplenc,Carl H. June,Stephan A. Grupp,Lisa Wray,Shannon L. Maude
出处
期刊:Blood Advances
[American Society of Hematology]
日期:2024-02-22
标识
DOI:10.1182/bloodadvances.2024012885
摘要
Relapse after CD19-directed chimeric antigen receptor (CAR)-modified T-cells remains a substantial challenge. Short CAR T-cell persistence contributes to relapse risk, necessitating novel approaches to prolong durability. CAR T-cell reinfusion (CARTr) represents a potential strategy to reduce the risk of, or treat, relapsed disease after initial CAR infusion (CARTi). We conducted a retrospective review of reinfusion of murine (CTL019) or humanized (huCART19) anti-CD19.4-1BB CAR T-cells across 3 clinical trials or commercial tisagenlecleucel for relapse prevention [peripheral B-cell recovery (BCR) or bone marrow hematogones ≤6 months after CARTi], minimal residual disease (MRD) or relapse, or nonresponse to CARTi. The primary endpoint was complete response (CR) at day 28 after CARTr, defined as complete remission with B-cell aplasia. Of 262 primary treatments, 81 were followed by ≥1 reinfusion (investigational CTL019, n=44; huCART19, n=26; tisagenlecleucel, n=11), representing 79 unique patients. Of 63 reinfusions for relapse prevention, 52% achieved CR (BCR, 15/40, 38%; hematogones, 18/23, 78%). Lymphodepletion was associated with response to CARTr for BCR (OR 33.57, P = 0.015), but not hematogones (OR 0.30, P = 0.291). The cumulative incidence of relapse was 29% at 24-months for CR versus 61% for nonresponse to CARTr (P=0.259). For MRD/relapse, CR rate to CARTr was 50% (5/10), but 0/8 for nonresponse to CARTi. Toxicity was generally mild, with the only grade ≥3 cytokine release syndrome (n=6) or neurotoxicity (n=1) observed in MRD/relapse treatment. Reinfusion of CTL019/tisagenlecleucel or huCART19 is safe, may reduce relapse risk in a subset of patients, and can reinduce remission in CD19-positive relapse.