流式细胞术
细胞疗法
遗传增强
计算生物学
细胞
癌症研究
分子生物学
生物
基因
遗传学
作者
Christopher A. Lazarski,Patrick J. Hanley
出处
期刊:Cytotherapy
[Elsevier]
日期:2024-02-01
卷期号:26 (2): 103-112
标识
DOI:10.1016/j.jcyt.2023.10.005
摘要
Abstract
Quality control testing and analytics are critical for the development and manufacture of cell and gene therapies, and flow cytometry is a key quality control and analytical assay that is used extensively. However, the technical scope of characterization assays and safety assays must keep apace as the breadth of cell therapy products continues to expand beyond hematopoietic stem cell products into producing novel adoptive immune therapies and gene therapy products. Flow cytometry services are uniquely positioned to support the evolving needs of cell therapy facilities, as access to flow cytometers, new antibody clones and improved fluorochrome reagents becomes more egalitarian. This report will outline the features, logistics, limitations and the current state of flow cytometry within the context of cellular therapy.
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