间充质干细胞
肌萎缩侧索硬化
干细胞
细胞外小泡
再生医学
疾病
神经科学
干细胞疗法
细胞疗法
多发性硬化
细胞内
细胞
再生(生物学)
医学
生物
生物信息学
细胞生物学
免疫学
病理
生物化学
作者
Mahmoud Kandeel,Mohamed A. Morsy,Khalid M. Alkhodair,Sameer M. Alhojaily
出处
期刊:Biomolecules
[MDPI AG]
日期:2023-08-16
卷期号:13 (8): 1250-1250
被引量:3
摘要
Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of biologically active elements, making them a promising approach for therapeutics and diagnostics. This article examines the potential therapeutic applications of MSC-derived EVs in addressing neurodegenerative disorders such as Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). Furthermore, the present state-of-the-art for MSC-EV-based therapy in AD, HD, PD, ALS, and MS is discussed. Significant progress has been made in understanding the etiology and potential treatments for a range of neurodegenerative diseases (NDs) over the last few decades. The contents of EVs are carried across cells for intercellular contact, which often results in the control of the recipient cell's homeostasis. Since EVs represent the therapeutically beneficial cargo of parent cells and are devoid of many ethical problems connected with cell-based treatments, they offer a viable cell-free therapy alternative for tissue regeneration and repair. Developing innovative EV-dependent medicines has proven difficult due to the lack of standardized procedures in EV extraction processes as well as their pharmacological characteristics and mechanisms of action. However, recent biotechnology and engineering research has greatly enhanced the content and applicability of MSC-EVs.
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